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$RAPTOR = Rapamycin + VCP/p97 activator Rapamycin needs no introduction, but it needs a dance partner for safe long-term use. The mTOR-independent autophagy activator SMER28 was discovered in a yeast-based phenotypic screen over 20 years go. Since then, it has been validated in multiple disease models in human cells, worms, flies, fish and rodents. The combination of SMER28 and rapamycin could be the basis of a potent and safe autophagy-boosting cocktail for healthspan and lifespan extension.