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Sima was the longest-living lab rat on record, thanks to a life-extending compound known as E5. Developed by Dr. Harold Katcher and Yuvan Research Inc., E5 is a plasma-derived formula designed to mimic the environment of youthful blood, which promotes cell and tissue rejuvenation. By periodically administering E5, researchers extended Sima's lifespan to over 47 months—around 126 human years—demonstrating the compound's potential to slow down or reverse certain signs of aging.