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Metastatic prostate cancer (also called advanced or stage 4 prostate cancer) is prostate cancer that has spread beyond the prostate gland to other parts of the body, most often the bones, lymph nodes, or distant organs. It is generally not curable, but treatments such as hormone therapy, chemotherapy, radiation, and targeted therapies can often control the disease, relieve symptoms, and extend life for years. Former U.S. President Joe Biden was diagnosed with an aggressive form of metastatic prostate cancer (Gleason score 9 with bone metastasis) in May 2025 and continues to live with and manage the disease as of August 2026.