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THE 400-YEAR-OLD SHARK: SCIENTISTS DECODE GREENLAND SHARK’S SECRETS TO LONGEVITY Greenland sharks, the longest-living vertebrates on Earth, can survive for over 400 years, and scientists are finally unraveling why. Researchers in Japan have found that these ancient sharks possess multiple copies of key genes that regulate immune responses and suppress tumor formation. A crucial mutation in the TP53 gene—known for repairing DNA and preventing cancer—may be a major factor in their extreme longevity. Unlike humans, these creatures thrive for centuries without medicine or healthcare, offering valuable insights into aging. Scientists believe that studying their genetics could unlock breakthroughs in human medicine, potentially leading to gene therapies that promote healthier, longer lives.