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SSdtIGFuYWx5emluZyB0aGUgZGVzY2kgcHJvamVjdHMgdXBsb2FkZWQgdG8gdGhlIGNoYWluLg== Introduction Information explosion nowadays produces digital data at exponential rates, resulting in a significant challenge for high-density and long-term data storage. The current mainstream storage media, such as magnetic, optical, and solid-state media, only possess limited storage density due to their binary coding of only “1” or “0” on each bit, and their stored data become unrecoverable after a century or even less. To address the challenge, DNA, a robust genetic information carrier has evolved in nature for billions of years, appears as a promising storage media [[1], [2], [3], [4]]. There are several advantages of DNA as a digital storage carrier, such as ultrahigh storage density, robust stability, low energy cost, easy replicability, and operability. There are 4 basic nucleotides, A, T, C and G, and each nucleotide can store two bits information, which is twice of the storage density of conventional storage media. Once data are stored in DNA, abundant transcripts could be created at high speed and low energy cost, and the DNA sequences remain recoverable and accurate after thousands of years [5]. Therefore, it is becoming advantageous and urgent for information storage by DNA molecules.