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Vita-FAST is developing new autophagy-inducing compounds for potential therapeutic applications. From our recent experiments we have identified 8 compounds from three lead series that are potent at inducing autophagy. From these we have ordered 60 new chemical entities (see VFDP-11) in order to explore the Structure Activity Relationship. These compounds have been identified prioritized and tested on the basis of three autophagy assays developed by the Korolchuk lab at the University of Newcastle. We would now like to, in addition to these assays, begin testing these compounds in worms for life extension as additional data to support the assays.
