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Omipalisib is a powerful mTOR and PI3K inhibitor. Originally developed to treat advanced cancers, it has recently been shown to extend the median lifespan in worms by as much as 63%! Unlike Rapamycin, Omipalisib directly inhibits mTORC1 and mTORC2. And even though it robustly boosts autophagy, taking this drug can be risky. But what happens when we combine Omipalisib with SMER28? As an mTOR-independent autophagy enhancer, SMER28 might allow us to greatly reduce the dose of Omipalisib we need, making it much safer and even more effective.
